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Herbesser 90 SR should be carefully administered in case of concomitant use with the following drugs:
Antihypertensive Agents: Effect of antihypertensive agents is enhanced.
Beta-Blocking Agents or Rauwolfia Preparations: Bradycardia may occur.
Carbamazepine: Plasma level of carbamazepine may be increased and it may cause carbamazepine-induced toxic symptoms eg, sleepiness, nausea, vomiting, vertigo, etc.
Digoxin Preparations: Plasma level of digoxin is increased.
Cimetidine: Peak plasma level of diltiazem and area under the curve may be increased.
The depression of cardiac contractility, conductivity and automaticity, as well as the vascular dilation associated with anesthetics may be potentiated by calcium antagonists. When used concomitantly, anesthetics and calcium antagonists should be titrated carefully.
